Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

Dengue poses a world well being menace, which can persist with out therapeutic intervention. Immunity induced by publicity to 1 serotype doesn’t confer long-term safety towards secondary an infection with different serotypes and is doubtlessly able to enhancing this an infection. Though vaccination is believed to induce sturdy and protecting responses towards all of the…

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Evaluating the performance of targeted sequence capture, RNA-Seq, and degenerate-primer PCR cloning for sequencing the largest mammalian multigene family.

Evaluating the performance of targeted sequence capture, RNA-Seq, and degenerate-primer PCR cloning for sequencing the largest mammalian multigene family.

Multigene households evolve from single-copy ancestral genes by way of duplication, and usually encode proteins essential to key organic processes. Molecular analyses of those gene households require high-confidence sequences, however the excessive sequence similarity of the members can create challenges for sequencing and downstream analyses. Specializing in the frequent vampire bat, Desmodus rotundus, we evaluated…

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