Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer

Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer

Sufferers with BRAF-mutated colorectal most cancers (CRC) have a poor prognosis regardless of latest therapeutic advances comparable to mixture remedy with BRAF, MEK, and EGFR inhibitors. To determine microRNAs (miRNAs) that may enhance the efficacy of the BRAF inhibitor dabrafenib (DAB) and the MEK inhibitor trametinib (TRA), we screened 240 miRNA in BRAF-mutated CRC cells…

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