FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens.

FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens.

FOXO3, which encodes the transcription issue forkhead field O-3 (FoxO3), is a member of the FOXO subfamily of the forkhead field (FOX) household. FOXO3 might be negatively regulated by its phosphorylation by the PI3K/Akt signaling pathway and in the end drives apoptosis when activated. In mammalian ovaries, the FOXO3 protein regulates atresia and follicle development…

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