Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.

• Preston

The enormous protein titin performs structure-preserving features within the sarcomere and is essential for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play essential roles in regulating myocardial contraction, hypertrophy, and reworking. PKD phosphorylates myofilament proteins, however it’s not identified whether or not the enormous protein titin can be a PKD substrate.…