
Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism
Preston
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Focused Twin Small Interfering Ribonucleic Acid Supply by way of Non-Viral Polymeric Vectors for Pulmonary Fibrosis Remedy
Scientific and Immunological Options of Platelet Transfusion Refractoriness in Younger Sufferers With De Novo Acute Myeloid Leukemia
RUNX1 mutation in a affected person with myelodysplastic syndrome and decreased erythrocyte expression of blood group A antigen.
Lack of blood group ABO antigens on crimson blood cells (RBCs) is well-known in sufferers with leukemias, and such decreased ABO expression has been reported to be strongly related to hypermethylation of the ABO promoter. We investigated the underlying mechanism answerable for A-antigen discount on RBCs in a affected person with myelodysplastic syndrome.Genetic evaluation of ABO was carried out by PCR and sequencing utilizing peripheral blood.
RT-PCR had been carried out utilizing cDNA ready from whole bone marrow (BM) cells. Bisulfite genomic sequencing was carried out utilizing genomic DNA from BM cells. Screening of somatic mutations was carried out utilizing a focused sequencing panel with genomic DNA from BM cells, adopted by transient transfection assays.
Genetic evaluation of ABO didn’t reveal any mutation in coding areas, splice websites, or regulatory areas. RT-PCR demonstrated discount of A-transcripts when the affected person’s RBCs weren’t agglutinated by anti-A antibody and didn’t point out any important enhance of other splicing merchandise within the affected person relative to the management.
Experiments involving transient transfection into Okay562 cells confirmed that the expression of ABO was decreased by expression of the mutated RUNX1.As a result of the RUNX1 mutation encoded an abnormally elongated protein with out a transactivation area which might act as dominant unfavourable inhibitor, this frame-shift mutation in RUNX1 could also be a genetic candidate contributing to A-antigen loss on RBCs.
Evaluation of the proteasome exercise and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma.
RUNX1 Antibody |
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1-CSB-PA020592GA01HU | Cusabio |
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Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
RUNX1 Antibody |
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CSB-PA020592KA01HU- | Cusabio | EUR 335 | |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
RUNX1 Antibody |
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CSB-PA020592KA01HU-100ul | Cusabio | 100ul | EUR 389 |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
RUNX1 Antibody |
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1-CSB-PA862035LA01HU | Cusabio |
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Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 |
RUNX1 Antibody |
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DF6785 | Affbiotech | 200ul | EUR 304 |
Description: RUNX1 Antibody detects endogenous levels of total RUNX1. |
RUNX1 Antibody |
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ABD6785 | Lifescience Market | 100 ug | EUR 438 |
RUNX1 antibody |
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10R-10936 | Fitzgerald | 100 ug | EUR 349 |
Description: Mouse monoclonal RUNX1 antibody |
RUNX1 antibody |
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10R-10998 | Fitzgerald | 100 ug | EUR 349 |
Description: Mouse monoclonal RUNX1 antibody |
RUNX1 antibody |
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10R-1279 | Fitzgerald | 100 ug | EUR 512 |
Description: Mouse monoclonal RUNX1 antibody |
RUNX1 antibody |
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70R-20046 | Fitzgerald | 50 ul | EUR 435 |
Description: Rabbit polyclonal RUNX1 antibody |
RUNX1 antibody |
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70R-51479 | Fitzgerald | 100 ul | EUR 244 |
Description: Purified Polyclonal RUNX1 antibody |
RUNX1 Antibody |
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5149-002mg | ProSci | 0.02 mg | EUR 171.82 |
Description: RUNX1 Antibody: RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF. |
RUNX1 Antibody |
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5149-01mg | ProSci | 0.1 mg | EUR 436.42 |
Description: RUNX1 Antibody: RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF. |
RUNX1 Polyclonal Antibody |
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ES7836-100ul | ELK Biotech | 100ul | EUR 279 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
RUNX1 Polyclonal Antibody |
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ES7836-50ul | ELK Biotech | 50ul | EUR 207 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
RUNX1 Polyclonal Antibody |
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ES7837-100ul | ELK Biotech | 100ul | EUR 279 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
RUNX1 Polyclonal Antibody |
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ES7837-50ul | ELK Biotech | 50ul | EUR 207 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
RUNX1 Polyclonal Antibody |
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ES7838-100ul | ELK Biotech | 100ul | EUR 279 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
RUNX1 Polyclonal Antibody |
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ES7838-50ul | ELK Biotech | 50ul | EUR 207 |
Description: A Rabbit Polyclonal antibody against RUNX1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
RUNX1 (pS276) Antibody |
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20-abx133011 | Abbexa |
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RUNX1 Polyclonal Antibody |
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ABP56837-003ml | Abbkine | 0.03ml | EUR 158 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |
RUNX1 Polyclonal Antibody |
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ABP56837-01ml | Abbkine | 0.1ml | EUR 289 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |
RUNX1 Polyclonal Antibody |
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ABP56837-02ml | Abbkine | 0.2ml | EUR 414 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |
RUNX1 Polyclonal Antibody |
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ABP56838-003ml | Abbkine | 0.03ml | EUR 158 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S276 |
RUNX1 Polyclonal Antibody |
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ABP56838-01ml | Abbkine | 0.1ml | EUR 289 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S276 |
RUNX1 Polyclonal Antibody |
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ABP56838-02ml | Abbkine | 0.2ml | EUR 414 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S276 |
RUNX1 Polyclonal Antibody |
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ABP56839-003ml | Abbkine | 0.03ml | EUR 158 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S249 |