
Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism
Preston
- 0

Focused Twin Small Interfering Ribonucleic Acid Supply by way of Non-Viral Polymeric Vectors for Pulmonary Fibrosis Remedy
Scientific and Immunological Options of Platelet Transfusion Refractoriness in Younger Sufferers With De Novo Acute Myeloid Leukemia
RUNX1 mutation in a affected person with myelodysplastic syndrome and decreased erythrocyte expression of blood group A antigen.
Lack of blood group ABO antigens on crimson blood cells (RBCs) is well-known in sufferers with leukemias, and such decreased ABO expression has been reported to be strongly related to hypermethylation of the ABO promoter. We investigated the underlying mechanism answerable for A-antigen discount on RBCs in a affected person with myelodysplastic syndrome.Genetic evaluation of ABO was carried out by PCR and sequencing utilizing peripheral blood.
RT-PCR had been carried out utilizing cDNA ready from whole bone marrow (BM) cells. Bisulfite genomic sequencing was carried out utilizing genomic DNA from BM cells. Screening of somatic mutations was carried out utilizing a focused sequencing panel with genomic DNA from BM cells, adopted by transient transfection assays.
Genetic evaluation of ABO didn’t reveal any mutation in coding areas, splice websites, or regulatory areas. RT-PCR demonstrated discount of A-transcripts when the affected person’s RBCs weren’t agglutinated by anti-A antibody and didn’t point out any important enhance of other splicing merchandise within the affected person relative to the management.
Experiments involving transient transfection into Okay562 cells confirmed that the expression of ABO was decreased by expression of the mutated RUNX1.As a result of the RUNX1 mutation encoded an abnormally elongated protein with out a transactivation area which might act as dominant unfavourable inhibitor, this frame-shift mutation in RUNX1 could also be a genetic candidate contributing to A-antigen loss on RBCs.
Evaluation of the proteasome exercise and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma.
RUNX1 Antibody |
|||
24886-100ul | SAB | 100ul | EUR 468 |
RUNX1 Antibody |
|||
ABD6785 | Lifescience Market | 100 ug | EUR 525.6 |
RUNX1 Antibody |
|||
1-CSB-PA070104 | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000 |
RUNX1 Antibody |
|||
1-CSB-PA070106 | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000 |
RUNX1 Antibody |
|||
1-CSB-PA862035LA01HU | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 |
RUNX1 Antibody |
|||
1-CSB-PA161481 | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:500-1:5000, WB:1:500-1:2000 |
RUNX1 Antibody |
|||
CSB-PA245126- | Cusabio | EUR 402 | |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
RUNX1 Antibody |
|||
CSB-PA245126-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
RUNX1 Antibody |
|||
1-CSB-PA020592GA01HU | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
RUNX1 Antibody |
|||
CSB-PA020592KA01HU- | Cusabio | EUR 402 | |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
RUNX1 Antibody |
|||
CSB-PA020592KA01HU-100ul | Cusabio | 100ul | EUR 466.8 |
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
RUNX1 Antibody |
|||
1-CSB-PA010571 | Cusabio |
|
|
Description: A polyclonal antibody against RUNX1. Recognizes RUNX1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000 |
RUNX1 Antibody |
|||
R31576 | NSJ Bioreagents | 100 ug | EUR 419 |
RUNX1 Antibody |
|||
F53076-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
RUNX1 Antibody |
|||
F53076-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
Runx1 Antibody |
|||
F53249-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
Runx1 Antibody |
|||
F53249-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
Runx1 Antibody |
|||
F53294-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
Runx1 Antibody |
|||
F53294-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
RUNX1 Antibody |
|||
F48224-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
RUNX1 Antibody |
|||
F48224-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
AML1(RUNX1) Antibody |
|||
21477-100ul | SAB | 100ul | EUR 302.4 |
AML1(RUNX1) Antibody |
|||
21477-50ul | SAB | 50ul | EUR 224.4 |
RUNX1 (pS276) Antibody |
|||
20-abx133011 | Abbexa |
|
|
RUNX1 Polyclonal Antibody |
|||
ABP56837-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |
RUNX1 Polyclonal Antibody |
|||
ABP56837-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |
RUNX1 Polyclonal Antibody |
|||
ABP56837-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of RUNX1 from Human, Mouse, Rat. This RUNX1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human RUNX1 around the non-phosphorylation site of S435 |